At the end of the first instalment of My Date with a Vampire, the Buddha Vairocana grants Fong Kwok-wah (Fong Tin-yau) his wish to travel back in time and be a vampire no more. In My Date with a Vampire II, Fong Kwok-wah and Yamamoto Kazuo clash again in 1938 and their fight arouses the attention of Cheung San, the progenitor of all vampires, who interrupts the fight. Just as Cheung San is about to bite the two men and turn them into vampires, Ma Dan-na appears and attacks Cheung San and drives him away, thus sparing Fong and Yamamoto from their fates. Not long later, Fong agrees to help Ma hunt down and destroy Cheung San. They succeed in trapping Cheung San but he breaks free, bites Fong and the boy Fuk-sang, and transforms them into vampires.  Fong Kwok-wah and Fuk-sang survive until the present-day (1990s) and their physical appearances have not changed since 60 years ago. However, before Fong became a vampire, he already had a son with his wife Sau, so he now has a grandson named Fong Tin-yau. Fong Tin-yau is killed in an incident in England so Fong Kwok-wah impersonates his grandson. He meets Ma Siu-ling (a descendant of Ma Dan-na), the heiress to a clan of ghostbusters who have dedicated themselves to ridding the world of evil supernatural beings. Fong starts a romance with Ma.  Nüwa, the goddess who created humankind in Chinese mythology, feels very disappointed and heartbroken after wtitnessing how her creations have become corrupted by evil. She intends to end the world on 2 January 2001. Cheung San existed long before the world came into existence, and he has a crush on Nüwa. Fong Tin-yau, Ma Siu-ling, and their friends plan to stop Nüwa from ending the world. However, they will come into conflict with not only the goddess herself, but also Cheung San and his followers.